Dimethylarsinothioyl glutathione
WebJul 13, 2007 · Dimethylarsinothioyl Glutathione as a Metabolite in Human Multiple Myeloma Cell Lines upon Exposure to Darinaparsin. Chemical Research in Toxicology 2014, 27 (5) , 754-764. DOI: 10.1021/tx400386c. Hua Naranmandura, Michael W. Carew, Shi Xu, Jane Lee, Elaine M. Leslie, Michael Weinfeld, and X. Chris Le . ... WebDimethylarsinothioyl glutathione as a metabolite in human multiple myeloma cell lines upon exposure to Darinaparsin
Dimethylarsinothioyl glutathione
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WebDarinaparsin, also known as ZIO-101, is a small-molecule organic arsenical with potential antineoplastic activity. Although the exact mechanism of action is unclear, darinaparsin, a highly toxic metabolic intermediate of inorganic arsenicals (iAs) that occurs in vivo, appears to generate volatile cytotoxic arsenic compounds when glutathione (GSH) … WebFeb 9, 2024 · Choline and DMG are present at higher levels in fetal versus maternal plasma, suggesting that choline provides glycine via DMG for glutathione synthesis in fetal …
WebHere we report the identification of dimethylarsinothioyl glutathione (DMMTAV (GS)) as a metabolite in cellular extracts of dimethyarsinous glutathione (Darinaparsin, DMAIII (GS)) treated human...
WebJan 5, 2004 · We apply QC-FPT to assign previously unassigned peaks in an experimental LC-ESI-MS² spectrum of dimethylarsinothioyl glutathione (Yehiayan et al., Chem. Res. Toxicol. 2014, 27, 754–764), and to ... WebMay 5, 2014 · Here, we report the identification of dimethylarsinothioyl glutathione (DMMTA V (GS)) as a metabolite in cellular extracts of dimethyarsinous glutathione …
WebSep 1, 2024 · The thirteen species included in this study are arsenite (As III), arsino-glutathione (As(GS) 3), arsenate ... (DMDTA V), dimethylarsinothioyl glutathione (DMMTA V (GS)). The developed method was applied for the analysis of cancer cells that were incubated with darinaparsin ...
WebDownload scientific diagram Common ions present in MS/MS fragmentation spectra of compound 14 and its three main biotransformation products. M1 – hydroxylated metabolite, M2 – debrominated ... how to join a college basketball teamWebMar 23, 2007 · Abstract. As biomolecules go: By identifying the dimethylarsinothioyl glutathione complex in arsenic-exposed cabbage, it was shown that pentavalent … how to join a college soccer teamWebJun 14, 2024 · It is also used to improve speech and behavior in autism, nervous system function, liver function, the body's use of oxygen, and athletic performance. Some people … how to join a club on rlWebReduced glutathione (GSH) is an abundant tripeptide present in the majority of cell types. GSH is highly reactive and is often conjugated to other molecules, via its sulfhydryl moiety. GSH is synthesized from glutamic acid, cysteine, and glycine via two sequential ATP‑consuming steps, which are catalyzed by glutamate cysteine ligase (GCL) and ... jorja smith discographyWebAcademic Departments. Back; Academic Departments Alabama College of Osteopathic ... Annals of Simulation jorja smith feat.burna boy be honestWebAug 25, 2006 · A complex of dimethylarsinothioyl glutathione was identified in cabbage plants grown in a hydroponic system treated with DMA V (Raab et al., 2007). jorja smith don\u0027t watch me cryWebDimethylarsinothioyl Glutathione as a Metabolite in Human Multiple Myeloma Cell Lines upon Exposure to Darinaparsin. Article. Mar 2014; Lucy Yehiayan; Szabina Stice; jorja smith ethnic background