WebJul 27, 2016 · The mechanisms by which infectious hepatitis C virus particles are assembled and released from the cell are poorly understood. We show that the virus subverts host cell trafficking pathways to effect the release of virus particles and disrupts the structure of the Golgi apparatus, a key cellular org … WebSep 10, 2024 · Understanding the host factors critical for Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication can identify new targets for therapeutic intervention. Using pharmacological and genetic silencing approaches, we reveal for the first time that KSHV requires a B cell expressed voltage-gated K+ channel, Kv1.3, to enhance lytic …
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WebJamel Mankouri Introduction Human respiratory syncytial virus (HRSV) is a common cause of respiratory tract infections (RTIs) globally and is one of the most fatal infectious … WebJamel Mankouri. Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT UK. Search for more papers by this author. Mark Harris, Corresponding Author. Mark Harris. [email protected] +44 113 343 5632 Fax: +44 113 343 5638; legendary s2
Requirement for chloride channel function during the hepatitis C …
WebJamel Mankouri Principal Scientist Nottingham, England, United Kingdom 575 followers 500+ connections Join to view profile Sygnature Discovery University of Leeds About Principal scientist... WebOct 7, 2024 · Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or “viroporins”, contrasting the success of channel blocking drugs in other areas of medicine. Although resistance arose to these prototypic adamantane inhibitors of the influenza A virus (IAV) M2 proton channel, a growing number of clinically … Web3 School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom [email protected]. PMID: 25609806 PMCID: PMC4403416 DOI: 10.1128/JVI.02946-14 Abstract Hepatocytes express an array of plasma membrane and intracellular ion channels, yet their role during the hepatitis C virus (HCV) … legendary sandevistan heatsink location