WebJan 17, 2012 · The LXR/RXR is a so-called permissive heterodimer; in that it can be activated by ligands for either LXR or RXR. The heterodimer binding to LXR-responsive elements (LXREs) in DNA consists of direct repeats (DRs) of the core sequence AGGTCA separated by 4 nucleotides (DR-4). WebMar 21, 2024 · Tocris Summary for NR1H2 Gene. Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear receptor … FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with … AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, … PPARGC1A (PPARG Coactivator 1 Alpha) is a Protein Coding gene. Diseases … NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) is a Protein Coding … KMT2C (Lysine Methyltransferase 2C) is a Protein Coding gene. Diseases … APOE (Apolipoprotein E) is a Protein Coding gene. Diseases associated with … CEBPB (CCAAT Enhancer Binding Protein Beta) is a Protein Coding gene. … ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. … NFKB1 (Nuclear Factor Kappa B Subunit 1) is a Protein Coding gene. Diseases … AKT2 (AKT Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases …
7376 - Gene ResultNR1H2 nuclear receptor subfamily 1 group H …
WebNational Center for Biotechnology Information WebApr 15, 2011 · The peroxisome proliferator-activated receptor (PPAR)γ and liver X receptor (LXR) nuclear receptors play important roles in both lipid metabolism and inflammation. 1 The endogenous agonists for PPARγ and LXR are fatty acids 2 and oxysterols, 3 respectively, and there is a large body of literature that has established both of these … stealth assessment shute 2011
Integrative analysis reveals multiple modes of LXR ... - PNAS
The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. Additionally, they play an important role in the local activation of thyroid hormones via deiodinases. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ i… WebLiver X Receptor. LXR is a sterol sensor that promotes lipogenesis, whereas PPARα controls a variety of genes in several pathways of lipid metabolism. ... Scd1 is eliminated … WebFeb 1, 2004 · The nuclear receptors liver X receptor (LXR)α and LXRβ are sensors of cholesterol metabolism and lipid biosynthesis. They have recently been found to be … stealth at18202p-3b filter