Mycothiazole
Web1 mrt. 2006 · Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon … WebA reinvestigation of the thiazole constituents from Cacospongia mycofijiensis, collected in Vanuatu, yielded known mycothiazole plus a new derivative, myc Rothiazole-4,19-diol, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid and possess cytotoxic properties that need further exploration. A …
Mycothiazole
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WebMycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and... DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone. WebExtensive experiences in Genetics, Bioinformatics, and Genome Editing. Learn more about Yang Liu's work experience, education, connections & more by visiting their profile on LinkedIn
WebThe synthesis of a potential key intermediate for the synthesis of the 4,19-diol derivative of (–)-mycothiazole using convergent strategies is described in this paper. Several … WebMycothiazole: Synthesis of the C8–C18 Subunit and Further Evidence of the (Z)‐Δ14 Double Bond Configuration . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up ...
WebThe synthesis of a potential key intermediate for the synthesis of the 4,19-diol derivative of (–)-mycothiazole using convergent strategies is described in this paper. Several approaches have been tested, including cross metathesis and a Julia–Kocienski olefination. WebA Petrosaspongia mycofijiensis marine sponge extract yielded mycothiazole (1), a solid tumor selective compound with no known mechanism for its cell line-dependent cytotoxic activity. Compound 1 inhibited hypoxic HIF-1 signaling in tumor cells (IC 50 1 nM) that correlated with the suppression of hypoxia-stimulated tumor angiogenesis in vitro.
Web4 sep. 2015 · Total Synthesis of the Potent HIF-1 Inhibitory Antitumor Natural Product, (8R)-Mycothiazole, via Baldwin-Lee CsF/CuI sp (3)-sp (2)-Stille Cross-Coupling. …
WebMycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial electron transport chain complex I in sensitive cells, but other cells are relatively insensitive to the drug. Sensitive cell lines (IC50 0.36–13.8 nM) include HeLa, P815, RAW 264.7, MDCK, HeLa … gulf shores parkingWeb30 dec. 2004 · A total synthesis of (±)-mycothiazole and a formal enantioselective approach have been achieved from 2,4-dibromothiazole. A chain extension of a homoallylic alcohol … bowie aestheticsWebmycothiazole (H3) was liberated alongside HPLC fractions H1 (0.1 mg), H2, Latrunculin A, (0.2 mg) and H4 (0.1 mg). Pure compounds were evaporated using a Nitrogen (N 2 ) … bowie 20716 weatherWeb1 jan. 2006 · The LCMS data collected during the reisolation of 3 was used to identify the other accompanying metabolites (see Figure S9) consisting of 1, 3 fijianolides A and B, 10a and polar fractions with m/z values 34 amu greater than 3.There were three such substances observed, and it was concluded that these were dihydrodiols of 3.Only one … gulf shores party boat fishingWebDoctor of Philosophy (Ph.D.)Synthetic Chemistry (Totyl synthesis) 2011 年 - 2015 年. Total synthesis study of antitumor natural alkaloids and a certain of methodologies. Developed the asymetric total synthesis of (+)-monachorine (14 steps) and first total synthesis of corrected (-)-mycothiazole (22 steps) independently. bowie advent calendarWeb15 aug. 2010 · Mycothiazole, originally derived from the marine sponge Petrosaspongia mycofijiensis, has been shown to have anticarcinoma impacts in cancerous cells via … bowie acoustic love balladsWeb30 jan. 2007 · The synthesis of mycothiazole derivatives was undertaken in order to have further evidence of the C14–C15 double bond configuration. The recently revised ( Z ) … bowie acoustic version of heroes