Shoc2 and cancer
WebSoc-2 suppressor of clear homolog (SHOC2) is a gene that encodes a protein that functions in the RAS/ERK MAP kinase signaling pathway as a scaffold linking Ras to downstream … Web15 Jul 2024 · The SHOC2-MRAS-PP1C (“SMP”) complex, a three-protein assembly, regulates the RAS signaling pathway and aids cancer cells with RAS mutations in survival. The high-resolution structure of this complex, revealed by X-ray crystallography and cryogenic electron microscopy , suggests potential drug binding sites for inhibiting the RAS pathway …
Shoc2 and cancer
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Web• Identify SHOC2 as a critical mediator of drug resistance in a mouse model with pancreatic tumor analyzed by t-test, ANOVA, and Kaplan-Meier method. ... Bladder cancer is one of the most frequent cancers among males, and its poor survival rate reflects problems with aggressiveness and chemo-resistance. Recent interest has focused on the use ... Webdriven lung cancer models, and significantly extends overall survival. Additionally, SHOC2 inhibition selectively sensitizes KRAS- and EGFR-mutant Non-small cell lung carcinoma (NSCLC) cells to MEK inhibitors. Mechanistically we show this is because SHOC2 is required for feedback-induced RAF dimerization, and as such combined
Web12 Mar 2024 · Furthermore, SHOC2 selectively binds to Raptor to competitively inhibit the Raptor-mTOR binding to inactivate mTORC1 and induce autophagy, whereas Raptor binding of SHOC2 inhibits the SHOC2-RAS binding to block the MAPK pathway and proliferation. Finally, SHOC2 is overexpressed in pancreatic cancer, which correlated with poor patient … WebSulahian, Kwon, and Walsh et al. performed several loss-of-function CRISPR-Cas9 screens in KRAS-mutant cancer cells treated with a MEK inhibitor and define the landscape of modifiers of MEK inhibitor sensitivity while highlighting that SHOC2 is a potent synthetic lethal target that serves as a critical signaling node to mediate MAP kinase pathway …
Web26 Nov 2024 · Happy to share our latest work on the SHOC2-MRAS-PP1C (SMP) complex which is now published online in Nature Structural and Molecular Biology. ... (NAD) mapping in twelve human cell lines (Cancer ... Web26 Oct 2024 · The potential SHOC2 inhibitor celastrol phenocopied SHOC2 depletion. In addition, we confirmed that SHOC2 expression levels were important for the sensitivity to EGFR-TKIs in vivo . Furthermore, IHC showed the accumulation of cancer cells that express high levels of SHOC2 in lung cancer tissues obtained from patients with NSCLC who …
WebIt affects around one in 1,000 to 2,500 individuals. Patients with Noonan Syndrome have an increased risk of developing several cancers that affect the blood (leukemia), nervous …
WebSHOC2 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, SHOC2 Genome Browser, SHOC2 References SHOC2 - Explore an overview of SHOC2, with a … furnished apartments warner robins gaWebERIKA ZARA. Titolo della tesi: Molecular bases of RAS superfamily-related diseases. The RAS GTPase pathway is involved in several key processes, essential in development and growth, so it is understandable that genetic mutations leading to dysregulated RAS function cause various types of diseases. Specifically, somatic mutations in RAS-related ... furnished apartment st petersburg flWebthe interest in these proteins primarily because of the central role that this cascade plays in cancer development. The important role of Raf in cancer ... scaffolding protein Sur-8/SHOC2.48 A complex between Sur-8/SHOC2 and the catalytic subunit of PP1c is an effector of the Ras family protein M-Ras, which can dephosphorylate ... github voron 2.4 officialWebSHOC2. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … furnished apartments waldorf mdWeb29 Jun 2024 · SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS11–13, but the structure of SHOC2 and the … github voron cfgWebMolecular Cell Article An MRAS, SHOC2, and SCRIB Complex Coordinates ERK Pathway Activation with Polarity and Tumorigenic Growth Lucy C. Young,1 Nicole Hartig,1,6 Marta Mun˜oz-Alegre,1,6 Juan A. Oses-Prieto,2 Sevi Durdu,3 Sabine Bender,1 Vineetha Vijayakumar,4 Matteo Vietri Rudan, 1Christina Gewinner, 1Stephen Henderson, Amit P. … github voron motor mountWebSuccinate dehydrogenase complex, subunit C, integral membrane protein (SDHC) is a gene that encodes a protein that is a component of succinate dehydrogenase. The protein anchors other proteins of the complex to the inner mitochondrial membrane. Missense and silent mutations are observed in cancers such as biliary tract cancer, ovarian cancer ... github volatility memory samples